Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study.

ABSTRACT: BACKGROUND:C1q nephropathy (C1qN) was first described as glomerular disease characterized by predominant meangial C1q deposits in patients with proteinuria and no evidence of systemic lupus erythematosus. Several studies, however, revealed the clinical heterogeneity of C1qN, showing some cases with normal urinalysis. To confirm the existence of cases with predominant mesangial C1q deposits and negative or mild proteinuria and/or hematuria, we investigated renal graft biopsy specimens showing negative to mild proteinuria (less than or equal to 1+ by dip stick test) and/or hematuria. METHODS:Eligible participants were kidney transplant cases who corresponded to the criteria for C1qN and were followed more than 10 years. Their medical records were reviewed to determine the age at detection of

SUBMITTER: Kanai T 

PROVIDER: S-EPMC5889604 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature