Division-independent differentiation mandates proliferative competition among stem cells.

ABSTRACT: Cancer-initiating gatekeeper mutations that arise in stem cells would be especially potent if they stabilize and expand an affected stem cell lineage. It is therefore important to understand how different stem cell organization strategies promote or prevent variant stem cell amplification in response to different types of mutation, including those that activate proliferation. Stem cell numbers can be maintained constant while producing differentiated products through individually asymmetrical division outcomes or by population asymmetry strategies in which individual stem cell lineages necessarily compete for niche space. We considered alternative mechanisms underlying population asymmetry and used quantitative modeling to predict starkly different consequences of altering proliferation ra

SUBMITTER: Reilein A 

PROVIDER: S-EPMC5889645 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature