Gibberellin DELLA signaling targets the retromer complex to redirect protein trafficking to the plasma membrane.

ABSTRACT: The plant hormone gibberellic acid (GA) is a crucial regulator of growth and development. The main paradigm of GA signaling puts forward transcriptional regulation via the degradation of DELLA transcriptional repressors. GA has also been shown to regulate tropic responses by modulation of the plasma membrane incidence of PIN auxin transporters by an unclear mechanism. Here we uncovered the cellular and molecular mechanisms by which GA redirects protein trafficking and thus regulates cell surface functionality. Photoconvertible reporters revealed that GA balances the protein traffic between the vacuole degradation route and recycling back to the cell surface. Low GA levels promote vacuolar delivery and degradation of multiple cargos, including PIN proteins, whereas high GA levels promote th

SUBMITTER: Salanenka Y 

PROVIDER: S-EPMC5889667 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature