Coarse particulate matter (PM_2.5-10) in Los Angeles Basin air induces expression of inflammation and cancer biomarkers in rat brains.

ABSTRACT: Air pollution is linked to brain inflammation, which accelerates tumorigenesis and neurodegeneration. The molecular mechanisms that connect air pollution with brain pathology are largely unknown but seem to depend on the chemical composition of airborne particulate matter (PM). We sourced ambient PM from Riverside, California, and selectively exposed rats to coarse (PM_2.5-10: 2.5-10 µm), fine (PM_<2.5: <2.5 µm), or ultrafine particles (UFPM: <0.15 µm). We characterized each PM type via atomic emission spectroscopy and detected nickel, cobalt and zinc within them. We then exposed rats separately to each PM type for short (2 weeks), intermediate (1-3 months) and long durations (1 year). All three metals accumulated in rat brains during intermediate-length PM exposures. V

SUBMITTER: Ljubimova JY 

PROVIDER: S-EPMC5890281 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature