Sponge Long Non-Coding RNAs Are Expressed in Specific Cell Types and Conserved Networks.

ABSTRACT: Although developmental regulation by long non-coding RNAs (lncRNAs) appears to be a widespread feature amongst animals, the origin and level of evolutionary conservation of this mode of regulation remain unclear. We have previously demonstrated that the sponge Amphimedon queenslandica-a morphologically-simple animal-developmentally expresses an array of lncRNAs in manner akin to more complex bilaterians (insects + vertebrates). Here, we first show that Amphimedon lncRNAs are expressed in specific cell types in larvae, juveniles and adults. Thus, as in bilaterians, sponge developmental regulation involves the dynamic, cell type- and context-specific regulation of specific lncRNAs. Second, by comparing gene co-expression networks between Amphimedon queenslandica and S

SUBMITTER: Gaiti F 

PROVIDER: S-EPMC5890393 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature