An Isolated TCR αβ Restricted by HLA-A*02:01/CT37 Peptide Redirecting CD8⁺ T Cells To Kill and Secrete IFN-γ in Response to Lung Adenocarcinoma Cell Lines.

ABSTRACT: Lung cancer is a leading cause of cancer-related death among both men and women in the United States, where non-small cell lung cancer accounts for ∼85% of lung cancer. Lung adenocarcinoma (ADC) is the major histologic subtype. The presence of actionable mutations prompts the use of therapies designed to specifically address the deleterious effects of those cancer-driving mutations; these therapies have already shown promise in cases carrying those actionable mutations (∼30%). Innovative therapeutic approaches are needed for the treatment of 70% of patients suffering from lung ADC. Adoptive transfer of CD8⁺ T cells specific against cancer/testis (CT) Ags, whose protein expression is restricted to the gonads (testis and ovary) and cancerous cells, is an excellent alternative. In

SUBMITTER: Flores-Villanueva PO 

PROVIDER: S-EPMC5890535 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature