Changes in macrophage transcriptome associate with systemic sclerosis and mediate <i>GSDMA</i> contribution to disease risk.

ABSTRACT:

Objectives

Several common and rare risk variants have been reported for systemic sclerosis (SSc), but the effector cell(s) mediating the function of these genetic variants remains to be elucidated. While innate immune cells have been proposed as the critical targets to interfere with the disease process underlying SSc, no studies have comprehensively established their effector role. Here we investigated the contribution of monocyte-derived macrophages (MDMs) in mediating genetic susceptibility to SSc.

Methods

We carried out RNA sequencing and genome-wide genotyping in MDMs from 57 patients with SSc and 15 controls. Our differential expression and expression quantitative trait locus (eQTL) analysis in SSc was further integrated with epigenetic, expression and eQTL data from s

SUBMITTER: Moreno-Moral A 

PROVIDER: S-EPMC5890626 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature