Differences in relative and absolute effectiveness of oral P2Y _₁₂ inhibition in men and women: a meta-analysis and modelling study.

ABSTRACT:

Objective

To estimate the absolute treatment effects of newer P2Y₁₂ inhibitors (ticagrelor and prasugrel) compared with clopidogrel in men and women with acute coronary syndrome (ACS).

Methods

We searched Ovid MEDLINE, Embase and the Cochrane Central Register of Controlled Trials for randomised controlled trials of oral P2Y₁₂ inhibitors for acute stroke or ACS. Age-specific and sex-specific mortality was obtained for all patients admitted to hospital with myocardial infarction in Scotland from 2006 to 2010 (prior to introduction of prasugrel or ticagrelor).

Results

From 9277 articles, nine fulfilled our inclusion criteria. Three trials compared newer P2Y₁₂ inhibitors to clopidogrel in ACS, in which the treatment rate ratio (RR) for maj

SUBMITTER: Lee KK 

PROVIDER: S-EPMC5890639 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature