Pretreatment HIV drug resistance results in virological failure and accumulation of additional resistance mutations in Ugandan children.

ABSTRACT:

Background

Pretreatment HIV drug resistance (PDR) can impair virological response to ART, jeopardizing effective treatment for children.

Methods

Children aged ≤12 years initiated first-line ART in Uganda during 2010-11. Baseline and 6 monthly viral load (VL) and genotypic resistance testing if VL >1000 copies/mL was done. The 2015 IAS-USA mutation list and Stanford algorithm were used to score drug resistance mutations (DRMs) and susceptibility. Virological failure (VF) was defined as two consecutive VLs >1000 copies/mL or death after 6 months of ART. Factors associated with failure and acquired drug resistance (ADR) were assessed in a logistic regression analysis.

Results

Among 317 children enrolled, median age was 4.9 years and 91.5% received NNRTI-based regimens. P

SUBMITTER: Kityo C 

PROVIDER: S-EPMC5890670 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature