Development and validation of the INCREMENT-ESBL predictive score for mortality in patients with bloodstream infections due to extended-spectrum-β-lactamase-producing Enterobacteriaceae.

ABSTRACT:

Background

Bloodstream infections (BSIs) due to ESBL-producing Enterobacteriaceae (ESBL-E) are frequent yet outcome prediction rules for clinical use have not been developed. The objective was to define and validate a predictive risk score for 30 day mortality.

Methods

A multinational retrospective cohort study including consecutive episodes of BSI due to ESBL-E was performed; cases were randomly assigned to a derivation cohort (DC) or a validation cohort (VC). The main outcome variable was all-cause 30 day mortality. A predictive score was developed using logistic regression coefficients for the DC, then tested in the VC.

Results

The DC and VC included 622 and 328 episodes, respectively. The final multivariate logistic regression model for mortality in the DC include

SUBMITTER: Palacios-Baena ZR 

PROVIDER: S-EPMC5890678 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature