Prevention of TB using rifampicin plus isoniazid reduces nevirapine concentrations in HIV-exposed infants.

ABSTRACT:

Background

Newborns of HIV-infected mothers are given daily doses of nevirapine to prevent HIV-1 acquisition. Infants born to mothers with TB should also receive TB preventive therapy. TB preventive regimens include isoniazid for 6 months or rifampicin plus isoniazid for 3 months (RH preventive therapy). The effect of concomitant RH preventive therapy on nevirapine concentrations in infants is unknown.

Patients and methods

Tshepiso was a prospective case-control cohort study of pregnant HIV-infected women with and without TB whose newborn infants received standard doses of nevirapine for HIV prophylaxis. Infants born to mothers with TB also received RH preventive therapy. Infant plasma nevirapine concentrations were measured at 1 and 6 weeks. The effects of RH preventive the

SUBMITTER: McIlleron H 

PROVIDER: S-EPMC5890683 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature