A randomized controlled trial of probiotics for Clostridium difficile infection in adults (PICO).

ABSTRACT:

Background

Clostridium difficile is the most common cause of hospital-acquired infections, responsible for >450000 infections annually in the USA. Probiotics provide a promising, well-tolerated adjunct therapy to standard C. difficile infection (CDI) treatment regimens, but there is a paucity of data regarding their effectiveness for the treatment of an initial CDI.

Objectives

We conducted a pilot randomized controlled trial of 33 participants from February 2013 to February 2015 to determine the feasibility and health outcomes of adjunct probiotic use in patients with an initial mild to moderate CDI.

Methods

The intervention was a 28 day, once-daily course of a four-strain oral probiotic capsule containing Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37

SUBMITTER: Barker AK 

PROVIDER: S-EPMC5890711 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature