Emerging multidrug resistance in community-associated Staphylococcus aureus involved in skin and soft tissue infections and nasal colonization.

ABSTRACT:

Background

Staphylococcus aureus is a major pathogen causing significant morbidity and mortality worldwide. The emergence of MDR S. aureus strains in the community setting has major implications in disease management. However, data regarding the occurrence and patterns of MDR community-associated S. aureus sub-clones is limited.

Objectives

To use whole-genome sequences to describe the diversity and distribution of resistance mechanisms among community-associated S. aureus isolates.

Methods

S. aureus isolates from skin and soft tissue infections (SSTIs) and nasal colonization were collected from patients within 10 primary care clinics from 2007 to 2015. The Illumina Miseq platform was used to determine the genome sequences for 144 S. aureus isolates. Phylogenetic and b

SUBMITTER: Lee GC 

PROVIDER: S-EPMC5890715 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature