Phenylephrine does not improve oxygenation during one-lung ventilation: A randomized, double-blind, cross-over study.

ABSTRACT:

Background

Phenylephrine is an α1 adrenergic receptor agonist that causes pulmonary vasoconstriction, and so may effectively enhance hypoxic pulmonary vasoconstriction (HPV). However, there is little evidence that phenylephrine augments HPV in clinical situations. This study aimed to evaluate the clinical effects of phenylephrine infusion on oxygenation during one-lung ventilation (OLV) in patients undergoing thoracic surgery.

Methods

This was a prospective, randomized, double-blind, cross-over study. Included patients were those undergoing elective thoracic surgery in the lateral decubitus position with OLV. Patients were randomly allocated to two groups. The N-P group initially had OLV with normal saline infusion for 30 minutes; after a 10 minute interval, OLV was then mai

SUBMITTER: Godai K 

PROVIDER: S-EPMC5891027 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature