X-ray-enhanced cancer cell migration requires the linker of nucleoskeleton and cytoskeleton complex.

ABSTRACT: The linker of nucleoskeleton and cytoskeleton (LINC) complex is a multifunctional protein complex that is involved in various processes at the nuclear envelope, including nuclear migration, mechanotransduction, chromatin tethering and DNA damage response. We recently showed that a nuclear envelope protein, Sad1 and UNC84 domain protein 1 (SUN1), a component of the LINC complex, has a critical function in cell migration. Although ionizing radiation activates cell migration and invasion in vivo and in vitro, the underlying molecular mechanism remains unknown. Here, we examined the involvement of the LINC complex in radiation-enhanced cell migration and invasion. A sublethal dose of X-ray radiation promoted human breast cancer MDA-MB-231 cell migration and invasion, whereas carbon ion beam ra

SUBMITTER: Imaizumi H 

PROVIDER: S-EPMC5891189 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature