Significance of tumor-infiltrating lymphocytes before and after neoadjuvant therapy for rectal cancer.

ABSTRACT: Neoadjuvant therapy for locally advanced rectal cancer is becoming increasingly common. However, biomarkers predicting the response to neoadjuvant therapy have not been established. Tumor-infiltrating lymphocytes (TILs) have a crucial effect on tumor progression and survival outcome as the primary host immune response, and an antitumor immune effect has been reported to contribute to the response to radiotherapy and chemotherapy. We investigated the significance of TILs before and after neoadjuvant treatment and the change in the density of those TILs. Sixty-four patients who underwent radical resection after neoadjuvant treatment for locally advanced rectal cancer were enrolled. The number of TIL subsets was examined using immunohistochemical staining of pretreatment biopsy samples and po

SUBMITTER: Matsutani S 

PROVIDER: S-EPMC5891199 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature