Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.

ABSTRACT:

Background

Molecular tests have clinical utility for thyroid nodules with indeterminate fine-needle aspiration (FNA) cytology, although their performance requires further improvement. This study evaluated the analytical performance of the newly created ThyroSeq v3 test.

Methods

ThyroSeq v3 is a DNA- and RNA-based next-generation sequencing assay that analyzes 112 genes for a variety of genetic alterations, including point mutations, insertions/deletions, gene fusions, copy number alterations, and abnormal gene expression, and it uses a genomic classifier (GC) to separate malignant lesions from benign lesions. It was validated in 238 tissue samples and 175 FNA samples with known surgical follow-up. Analytical performance studies were conducted.

Results

In the training

SUBMITTER: Nikiforova MN 

PROVIDER: S-EPMC5891361 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature