Racial disparities in prostate cancer survival in a screened population: Reality versus artifact.

ABSTRACT:

Background

Racial disparities in prostate cancer survival (PCS) narrowed during the prostate-specific antigen (PSA) era, suggesting that screening may induce more equitable outcomes. However, the effects of lead time and overdiagnosis can inflate survival even without real screening benefit.

Methods

A simulation model of PCS in the early PSA era (1991-2000) was created. The modeled survival started with baseline survival in the pre-PSA era (1975-1990) and added lead times and overdiagnosis using estimates from published studies. The authors quantified 1) discrepancies between modeled and observed PCS in the PSA era and 2) residual period effects on PCS given specified values for screening benefit.

Results

Lead time and overdiagnosis explained more of the improvement i

SUBMITTER: Kaur D 

PROVIDER: S-EPMC5891383 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature