Restricted mean survival time: Does covariate adjustment improve precision in randomized clinical trials?

ABSTRACT:

Background

Restricted mean survival time is a measure of average survival time up to a specified time point. There has been an increased interest in using restricted mean survival time to compare treatment arms in randomized clinical trials because such comparisons do not rely on proportional hazards or other assumptions about the nature of the relationship between survival curves.

Methods

This article addresses the question of whether covariate adjustment in randomized clinical trials that compare restricted mean survival times improves precision of the estimated treatment effect (difference in restricted mean survival times between treatment arms). Although precision generally increases in linear models when prognostic covariates are added, this is not necessarily the case

SUBMITTER: Karrison T 

PROVIDER: S-EPMC5891397 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature