Pleiotropic Contribution of MECOM and AVPR1A to Aggression and Subcortical Brain Volumes.

ABSTRACT: Reactive and proactive subtypes of aggression have been recognized to help parse etiological heterogeneity of this complex phenotype. With a heritability of about 50%, genetic factors play a role in the development of aggressive behavior. Imaging studies implicate brain structures related to social behavior in aggression etiology, most notably the amygdala and striatum. This study aimed to gain more insight into the pathways from genetic risk factors for aggression to aggression phenotypes. To this end, we conducted genome-wide gene-based cross-trait meta-analyses of aggression with the volumes of amygdala, nucleus accumbens and caudate nucleus to identify genes influencing both aggression and aggression-related brain volumes. We used data of large-scale genome-wide association studies (GW

SUBMITTER: van Donkelaar MMJ 

PROVIDER: S-EPMC5891600 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature