Stem Cell Transcription Factor FoxO Controls Microbiome Resilience in Hydra.

ABSTRACT: The aging process is considered to be the result of accumulating cellular deterioration in an individual organism over time. It can be affected by the combined influence of genetic, epigenetic, and environmental factors including life-style-associated events. In the non-senescent freshwater polyp Hydra, one of the classical model systems for evolutionary developmental biology and regeneration, transcription factor FoxO modulates both stem cell proliferation and innate immunity. This provides strong support for the role of FoxO as a critical rate-of-aging regulator. However, how environmental factors interact with FoxO remains unknown. Here, we find that deficiency in FoxO signaling in Hydra leads to dysregulation of antimicrobial peptide expression and that FoxO loss-of-funct

SUBMITTER: Mortzfeld BM 

PROVIDER: S-EPMC5891625 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature