The VEGFA₁₅₆b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease.

ABSTRACT: Coronary heart disease (CHD) is a leading cause of morbidity in people over 65 years of age; >40% of all deaths are due to this condition. The association between increasing age and CHD is well documented; the accumulation of senescent cells in cardiac and vascular tissues may represent one factor underpinning this observation. We aimed to identify senescence-related expression changes in primary human senescent cardiomyocytes and endothelial cells and to relate transcript expression in peripheral blood leucocytes to prevalent and incident CHD in the InCHIANTI study of aging. We quantified splicing factor expression and splicing patterns of candidate transcripts in proliferative and senescent later passage endothelial cells and cardiomyocytes using qRTPCR. Senescence-associated isoforms al

SUBMITTER: Latorre E 

PROVIDER: S-EPMC5891722 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature