Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma.

ABSTRACT:

Background

Although pre-puberty asthma is more prevalent in males, after puberty through middle-age, asthma is more prevalent in females. The surge of sex hormones with puberty might explain this gender switch.

Methods

To examine the effects of sex hormones on lung function and symptoms with puberty, Tanner stage was assessed in 187 children 6-18 years of age (59% severe) enrolled in the NIH/NHLBI Severe Asthma Research Program (SARP). The effects of circulating sex hormones (n = 68; testosterone, dehydroepiandrosterone sulfate (DHEA-S), estrogen, and progesterone) on lung function and 4 week symptom control (ACQ6) in cross-section were tested by linear regression.

Results

From pre-/early to late puberty, lung function did not change significantly but ACQ6 scores impr

SUBMITTER: DeBoer MD 

PROVIDER: S-EPMC5891903 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature