Effect of low energy diet for eight weeks to adults with overweight or obesity on folate, retinol, vitamin B₁₂, D and E status and the degree of inflammation: a post hoc analysis of a randomized intervention trial.

ABSTRACT:

Background

Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B₁₂, D and E status and the degree of inflammation.

Methods

Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m², completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B₁₂, D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED.

Results

At baseline, 8% of the participants were deficient in folate, 13% in vitamin B₁₂, 2% in retinol, 28% in vitamin D (72% were insufficient in vitamin D), and none were deficient in vitamin E. At baseline, BMI was inversely associated with retinol (P < 0.05) as was total and abdominal fat percentage with folate (P < 0.05); further BMI and measures of adiposity were positively associated with CRP (P < 0.01) and Hcy (P < 0.05). Homocysteine was inversely associated with all vitamins but retinol (P < 0.001). After the LED, the participants lost a mean [95% confidence intervals] of 12.3 [- 13.1,-11.6] kg. The serum concentration of folate, vitamin B₁₂ and D were increased (P < 0.001) after the LED whereas the concentration of retinol and vitamin E were reduced (P < 0.001).

Conclusion

Eight-weeks LED resulted in 13% weight loss and an increase in the serum concentrations of folate, vitamin B₁₂ and D. Baseline adiposity was inversely associated with folate and retinol, and positively associated with markers of inflammation.

Trial registration

Ethical Committee of Copenhagen as no. H-4-2013-135, NCT01561131.

SUBMITTER: Geiker NRW 

PROVIDER: S-EPMC5891925 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature