H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia.

ABSTRACT:

Background

The long non-coding RNA H19 plays a crucial role in solid tumor initiation and progression. However, the potential role of H19 and its clinical significance in acute myeloid leukemia (AML) remain largely elusive.

Methods

H19 expression was detected by qPCR, and clinical significance in AML patients was further analyzed. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data for AML were used as validation cohorts. The roles of H19 in cell proliferation and apoptosis were determined by cell proliferation assay and flow cytometry analysis.

Results

H19 expression was significantly increased in AML patients but not associated with embedded miR-675 expression. Moreover, H19 overexpression was not de

SUBMITTER: Zhang TJ 

PROVIDER: S-EPMC5891930 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature