Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage.

ABSTRACT:

Background

Commitment of pluripotent stem cells into differentiated cells and associated gene expression necessitate specific epigenetic mechanisms that modify the DNA and corresponding histone proteins to render the chromatin in an open or closed state. This in turn dictates the associated genetic machinery, including transcription factors, acknowledging the cellular signals provided. Activating histone methyltransferases represent crucial enzymes in the epigenetic machinery that cause transcription initiation by delivering the methyl mark on histone proteins. A number of studies have evidenced the vital role of one such histone modifier, DOT1L, in transcriptional regulation. Involvement of DOT1L in differentiating pluripotent human embryonic stem (hES) cells into the cardiac line

SUBMITTER: Pursani V 

PROVIDER: S-EPMC5891944 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature