Prospective, randomized, double-blind, placebo-controlled phase IIa clinical trial on the effects of an estrogen-progestin combination as add-on to inpatient psychotherapy in adult female patients suffering from anorexia nervosa.

ABSTRACT:

Background

There is a need for novel treatment approaches in anorexia nervosa (AN). While there is broad knowledge with regard to altered appetite regulation and neuropsychological deficits in AN patients on the one hand, and the effects of estrogen replacement upon neuropsychological performance in healthy subjects on the other, up to now, no study has implemented estrogen replacement in AN patients, in order to examine its effects upon AN-associated and general psychopathology, neuropsychological performance and concentrations of peptide components of the hypothalamus-pituitary-adrenal (HPA) axis and within appetite-regulating circuits.

Methods

This is a randomized placebo-controlled clinical trial on the effects of a 10-week oral estrogen replacement (combination of ethin

SUBMITTER: Paslakis G 

PROVIDER: S-EPMC5891970 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature