Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome.

ABSTRACT:

Background

Social impairments are described as a common feature of the 22q11.2 deletion syndrome (22q11DS). However, the neural correlates underlying these impairments are largely unknown in this population. In this study, we investigated neural substrates of socio-emotional perception.

Methods

We used event-related functional magnetic resonance imaging (fMRI) to explore neural activity in individuals with 22q11DS and healthy controls during the visualization of stimuli varying in social (social or non-social) or emotional (positive or negative valence) content.

Results

Neural hyporesponsiveness in regions of the default mode network (inferior parietal lobule, precuneus, posterior and anterior cingulate cortex and frontal regions) in response to social versus non-soci

SUBMITTER: Dubourg L 

PROVIDER: S-EPMC5891973 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature