Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas.

ABSTRACT:

Background

Rare multicentric lower-grade gliomas (LGGs) represent a unique opportunity to study the heterogeneity among distinct tumor foci in a single patient and to infer their origins and parallel patterns of evolution.

Methods

In this study, we integrate clinical features, histology, and immunohistochemistry for 4 patients with multicentric LGG, arising both synchronously and metachronously. For 3 patients we analyze the phylogeny of the lesions using exome sequencing, including one case with a total of 8 samples from the 2 lesions.

Results

One patient was diagnosed with multicentric isocitrate dehydrogenase 1 (IDH1) mutated diffuse astrocytomas harboring distinct IDH1 mutations, R132H and R132C; the latter mutation has been associated with Li-Fraumeni syndrome, w

SUBMITTER: Hayes J 

PROVIDER: S-EPMC5892142 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature