Diabetes is Not Associated with Alzheimer's Disease Neuropathology.

ABSTRACT:

Background

Previous evidence linking diabetes to Alzheimer's disease (AD) neuropathology is mixed and scant data are available from low- and middle-income countries.

Objective

To investigate the association between diabetes and AD neuropathology in a large autopsy study of older Brazilian adults.

Methods

In this cross-sectional study, diabetes was defined by diagnosis during life or use of antidiabetic medication. A standardized neuropathological examination was performed using immunohistochemistry. The associations of diabetes with Consortium to Establish and Registry for Alzheimer Disease (CERAD) scores for neuritic plaques and Braak-Braak (BB) scores for neurofibrillary tangles were investigated using multivariable ordinal logistic regression. We investigated effec

SUBMITTER: Dos Santos Matioli MNP 

PROVIDER: S-EPMC5892204 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature