Tailoring the morphology of AIEgen fluorescent nanoparticles for optimal cellular uptake and imaging efficacy.

ABSTRACT: The rational design of robust fluorescent organic materials for long-term cell tracing is still challenging, and aggregation-caused quenching of emission is a big limitation of this strategy. Organic dyes with aggregation-induced emission (AIE) can effectively address this problem. Herein, AIEgen-containing nanoparticles, with different morphologies and emission, were prepared by assembling amphiphilic copolymers with an AIEgen. We compared the physical and chemical properties of rod-like and spherical nanoparticles, particularly investigating the effects of the shape on internalization and the imaging effect. The formulated nanoparticles exhibit advantageous features, such as a large Stokes shift, robust stability in physiological conditions, strong fluorescent emission, and photobleachin

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5892346 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature