Comparison of topical and intravenous administration of tranexamic acid for blood loss control during total joint replacement: Review of literature.

ABSTRACT:

Purpose

Many randomised controlled trials and meta-analysis studies have presented the efficacy of tranexamic acid (TXA) without an increase of complications. However, questions still remain about the type of administration, optimal dose and secondary outcomes of TXA in total hip arthroplasty and total knee arthroplasty. The aim of this review is to summarise the existing information in literature concerning the pharmacological characteristics of TXA, forms, doses, types of application and contraindications for its use.

Methods

A literature review containing 63 articles from the PubMed data starting from the first description of tranexamic acid until now was made in trying to present the existing information in a simple and effective way.

Results

TXA leads to statisti

SUBMITTER: Georgiev GP 

PROVIDER: S-EPMC5892384 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature