In Brachypodium a complex signaling is actuated to protect cells from proteotoxic stress and facilitate seed filling.

ABSTRACT:

Main conclusion

A conserved UPR machinery is required for Brachypodium ER stress resistance and grain filling. Human and livestock diets depend on the accumulation of cereal storage proteins and carbohydrates, including mixed-linkage glucan (MLG), in the endosperm during seed development. Storage proteins and proteins responsible for the production of carbohydrates are synthesized in the endoplasmic reticulum (ER). Unfavorable conditions during growth that hamper the ER biosynthetic capacity, such as heat, can cause a potentially lethal condition known as ER stress, which activates the unfolded protein response (UPR), a signaling response designed to mitigate ER stress. The UPR relies primarily on a conserved ER-associated kinase and ribonuclease, IRE1, which splices the mRNA of a

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC5892453 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature