Cross-kingdom auxiliary subunit modulation of a voltage-gated sodium channel.

ABSTRACT: Voltage-gated, sodium ion-selective channels (Na_V) generate electrical signals contributing to the upstroke of the action potential in animals. Na_Vs are also found in bacteria and are members of a larger family of tetrameric voltage-gated channels that includes Ca_Vs, K_Vs, and Na_Vs. Prokaryotic Na_Vs likely emerged from a homotetrameric Ca²⁺-selective voltage-gated progenerator, and later developed Na⁺ selectivity independently. The Na_V signaling complex in eukaryotes contains auxiliary proteins, termed beta (β) subunits, which are potent modulators of the expression profiles and voltage-gated properties of the Na_V pore, but it is unknown whether they can functionally interact with p

SUBMITTER: Molinarolo S 

PROVIDER: S-EPMC5892571 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature