Solution structure of the cytochrome P450 reductase-cytochrome c complex determined by neutron scattering.

ABSTRACT: Electron transfer in all living organisms critically relies on formation of complexes between the proteins involved. The function of these complexes requires specificity of the interaction to allow for selective electron transfer but also a fast turnover of the complex, and they are therefore often transient in nature, making them challenging to study. Here, using small-angle neutron scattering with contrast matching with deuterated protein, we report the solution structure of the electron transfer complex between cytochrome P450 reductase (CPR) and its electron transfer partner cytochrome c This is the first reported solution structure of a complex between CPR and an electron transfer partner. The structure shows that the interprotein interface includes residues from both the FMN-

SUBMITTER: Freeman SL 

PROVIDER: S-EPMC5892573 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature