Association between WWOX and the risk of malignant tumor, especially among Asians: evidence from a meta-analysis.

ABSTRACT:

Purpose

Many studies have been carried out to examine whether there are associations between WWOX polymorphisms (rs3764340 C>G, rs12918952 G>A, and rs383362 G>T) and malignant tumor risk, but the results from these studies remained inconsistent and even controversial. In the present study, we performed a meta-analysis to evaluate the relationships comprehensively.

Methods

Published reports were searched in PubMed, Google Scholar, and Chinese National Knowledge Infrastructure databases. Eight eligible case-control studies were included in the final analysis. In the analysis, pooled odds ratios (ORs) with corresponding 95% CIs were calculated in five genetic models to assess the genetic risk. Egger's regression and Begg's funnel plots test were conducted to appraise the public

SUBMITTER: Yuan H 

PROVIDER: S-EPMC5892619 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature