Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice.

ABSTRACT: Diet-related health issues such as nonalcoholic fatty liver disease and cardiovascular disorders are known to have a major inflammatory component. However, the exact pathways linking diet-induced changes (e.g., hyperlipidemia) and the ensuing inflammation have remained elusive so far. We identified biological processes related to innate immunity and oxidative stress as prime response pathways in livers of low-density lipoprotein receptor-deficient mice on a Western-type diet using RNA sequencing and in silico functional analyses of transcriptome data. The observed changes were independent of the presence of microbiota and thus indicative of a role for sterile triggers. We further show that malondialdehyde (MDA) epitopes, products of lipid peroxidation and markers for enhanced oxidative str

SUBMITTER: Busch CJ 

PROVIDER: S-EPMC5892702 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature