The trafficking protein, EHD2, positively regulates cardiac sarcolemmal K_ATP channel surface expression: role in cardioprotection.

ABSTRACT: ATP-sensitive K⁺ (K_ATP) channels uniquely link cellular energy metabolism to membrane excitability and are expressed in diverse cell types that range from the endocrine pancreas to neurons and smooth, skeletal, and cardiac muscle. A decrease in the surface expression of K_ATP channels has been linked to various disorders, including dysregulated insulin secretion, abnormal blood pressure, and impaired resistance to cardiac injury. In contrast, up-regulation of K_ATP channel surface expression may be protective, for example, by mediating the beneficial effect of ischemic preconditioning. Molecular mechanisms that regulate K_ATP channel trafficking are poorly understood. Here, we used cellular assays with immunofluorescence, surface biotinyl

SUBMITTER: Yang HQ 

PROVIDER: S-EPMC5892718 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature