Pathways of association between maternal haemoglobin and stillbirth: path-analysis of maternity data from two hospitals in England.

ABSTRACT:

Objective

To investigate the mechanisms that link maternal haemoglobin concentration with stillbirth.

Design

A retrospective cohort analysis using anonymised maternity data from two hospitals in England.

Setting

The Royal Wolverhampton NHS Trust and Guy's and St Thomas' NHS Foundation Trust.

Study population

12 636 women with singleton pregnancies ≥24 weeks of gestation giving birth in the two hospitals during 2013-2015.

Method

A conceptual framework of hypothesised pathways through birth weight-for-gestational age and maternal infection including potential confounders and other risk factors was developed and examined using path-analysis. Path-analysis was performed by fitting a set of regression equations using weighted least squares adjusted for mean a

SUBMITTER: Nair M 

PROVIDER: S-EPMC5892753 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature