Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials.

ABSTRACT:

Objective

Iron supplementation in iron-deficiency anaemia is standard practice, but the benefits of iron supplementation in iron-deficient non-anaemic (IDNA) individuals remains controversial. Our objective is to identify the effects of iron therapy on fatigue and physical capacity in IDNA adults.

Design

Systematic review and meta-analysis of randomised controlled trials (RCTs).

Setting

Primary care.

Participants

Adults (≥18 years) who were iron deficient but non-anaemic.

Interventions

Oral, intramuscular or intravenous iron supplementation; all therapy doses, frequencies and durations were included.

Comparators

Placebo or active therapy.

Results

We identified RCTs in Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulati

SUBMITTER: Houston BL 

PROVIDER: S-EPMC5892776 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature