Transforming growth factor-β1 activates ΔNp63/c-Myc to promote oral squamous cell carcinoma.

ABSTRACT:

Objective

During the development of oral squamous cell carcinoma (OSCC), the transformed epithelial cells undergo increased proliferation resulting in tumor growth and invasion. Interestingly, throughout all phases of differentiation and progression to OSCC, transforming growth factor-β1 (TGF)-β1 induces cell cycle arrest or apoptosis; however, the role of TGF-β1 in promoting cancer cell proliferation has not been explored in detail. The purpose of this study was to identify the effect of TGF-β1 on OSCC cell proliferation.

Study design

Using both human OSCC samples and cell lines (UMSCC38 and UMSCC11B), we assessed protein, mRNA, gene expression, and protein-DNA interactions during OSCC progression.

Results

Our results showed that TGF-β1 increased OSCC cell proliferat

SUBMITTER: Hu L 

PROVIDER: S-EPMC5892788 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature