Acute glomerulonephritis with large confluent IgA-dominant deposits associated with liver cirrhosis.

ABSTRACT:

Background

Small glomerular IgA deposits have been reported in patients with liver cirrhosis, mainly as an incidental finding in autopsy studies. We recently encountered nine cirrhotic patients who presented with acute proliferative glomerulonephritis with unusually large, exuberant glomerular immune complex deposits, in the absence of systemic lupus erythematosus (SLE) or monoclonal gammopathy-related kidney disease. Deposits were typically IgA dominant/codominant. Our aim was to further elucidate the etiology, diagnostic pitfalls, and clinical outcomes.

Methods

We present clinical features and kidney biopsy findings of nine cirrhotic patients with an unusual acute immune complex glomerulonephritis. We also identified native kidney biopsies from all patients with liver cirr

SUBMITTER: Hemminger J 

PROVIDER: S-EPMC5892865 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature