Proteomic analysis of human epileptic neocortex predicts vascular and glial changes in epileptic regions.

ABSTRACT: Epilepsy is a common neurological disorder, which is not well understood at the molecular level. Exactly why some brain regions produce epileptic discharges and others do not is not known. Patients who fail to respond to antiseizure medication (refractory epilepsy) can benefit from surgical removal of brain regions to reduce seizure frequency. The tissue removed in these surgeries offers an invaluable resource to uncover the molecular and cellular basis of human epilepsy. Here, we report a proteomic study to determine whether there are common proteomic patterns in human brain regions that produce epileptic discharges. We analyzed human brain samples, as part of the Systems Biology of Epilepsy Project (SBEP). These brain pieces are in vivo electrophysiologically characterized human brain sa

SUBMITTER: Keren-Aviram G 

PROVIDER: S-EPMC5892923 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature