Large scale newborn deafness genetic screening of 142,417 neonates in Wuhan, China.

ABSTRACT: Almost one third of the three million people in China suffering severe deafness are children, and 50% of these cases are believed to have genetic components to their etiology. Newborn hearing genetic screening can complement Universal Neonatal Hearing Screening for the diagnosis of congenital hearing loss as well as identifying children at risk for late-onset and progressive hearing impairment. The aim of this joint academic and Ministry of Health project was to prototype a cost effective newborn genetic screen in a community health setting on a city-wide level, and to ascertain the prevalence of variation at loci that have been associated with non-syndromic hearing loss. With the participation of 143 local hospitals in the city of Wuhan, China we screened 142,417 neonates born between May

SUBMITTER: Hao Z 

PROVIDER: S-EPMC5892933 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature