SARNAclust: Semi-automatic detection of RNA protein binding motifs from immunoprecipitation data.

ABSTRACT: RNA-protein binding is critical to gene regulation, controlling fundamental processes including splicing, translation, localization and stability, and aberrant RNA-protein interactions are known to play a role in a wide variety of diseases. However, molecular understanding of RNA-protein interactions remains limited; in particular, identification of RNA motifs that bind proteins has long been challenging, especially when such motifs depend on both sequence and structure. Moreover, although RNA binding proteins (RBPs) often contain more than one binding domain, algorithms capable of identifying more than one binding motif simultaneously have not been developed. In this paper we present a novel pipeline to determine binding peaks in crosslinking immunoprecipitation (CLIP) data, to discover m

SUBMITTER: Dotu I 

PROVIDER: S-EPMC5892938 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature