Prenatal exposure to nitrosatable drugs, vitamin C, and risk of selected birth defects.

ABSTRACT:

Unlabelled

Nitrosatable drugs, such as secondary or tertiary amines and amides react with nitrite in an acidic environment to form N-nitroso compounds, teratogens in animal models. Vitamin C is a known nitrosation inhibitor.

Methods

Using data from the National Birth Defects Prevention Study, we assessed nitrosatable drug exposure and vitamin C intake during the first trimester among 11,606 case-mothers of infants with oral clefts, limb deficiencies (LDs), or congenital heart defects and 6807 control-mothers of infants without major birth defects during 1997-2005. Daily intake of vitamin C was estimated from maternal interviews that elicited information about supplement use and dietary intake.

Results

With no reported use of nitrosatable drugs as the referent group, a

SUBMITTER: Shinde MU 

PROVIDER: S-EPMC5893146 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature