CD30 expression and survival in extranodal NK/T-cell lymphoma: a systematic review and meta-analysis.

ABSTRACT:

Background

The paradoxical reports about the prognostic value of the CD30 expression in extranodal NK/T-cell lymphoma (ENKTL) have restricted its further applications in clinical practice. To identify the common effects and the variation, we conducted this systematic review and meta-analysis.

Methods

PubMed, MEDLINE, Embase, and Web of Science were searched between January 1975 and 31 January 2017. The pooled hazard ratio was used to estimate the effect of the CD30 expression on overall survival. Bias was assessed by prespecified criteria referring to Reporting Recommendations for Tumor Marker Prognostic Studies and Newcastle-Ottawa Scale.

Results

Ten retrospective cohort studies with 310 patients are included. CD30 is associated with better overall survival significa

SUBMITTER: Chen Z 

PROVIDER: S-EPMC5893261 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature