The effect of vitamin D on renin-angiotensin system activation and blood pressure: a randomized control trial.

ABSTRACT:

Objective

Disruption of vitamin D signaling in rodents causes activation of the rennin-angiotensin system (RAS) and development of hypertension. Observational studies in humans found lower circulating 25-hydroxyvitamin D [25(OH)D] is associated with increased RAS activity and blood pressure (BP). We performed the first randomized control trial to investigate the effects of vitamin D supplementation on the RAS in humans.

Methods

Vitamin D deficient, [25(OH)D ≤20 ng/ml), overweight individuals without hypertension were randomized into a double-blind, placebo-controlled trial of 8-weeks treatment with ergocalciferol or placebo. Kidney-specific RAS activity, measured using renal plasma flow response to captopril in high sodium balance, was assessed at baseline and 8 weeks, as wa

SUBMITTER: McMullan CJ 

PROVIDER: S-EPMC5893307 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature