Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats.

ABSTRACT:

Introduction

There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur.

Methods

This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40).

Results

Amphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affec

SUBMITTER: Ruiz P 

PROVIDER: S-EPMC5893334 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature