The association between HSD3B7 gene variant and Parkinson's disease in ethnic Chinese.

ABSTRACT:

Objectives

Studies at the genomewide level of Parkinson's disease (PD) suggested a significant association between the Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta isomerase 7 (HSD3B7) gene rs9938550 variant and a decreased risk for PD. But its effect has only been discussed in Caucasian populations, and no phenotypic characteristics were included. To investigate the novel variant for PD in Chinese Han populations, we performed an association analysis of rs9938550 variant in a large cohort.

Methods

Using a case-control methodology, a total of 2,239 subjects (1,072 sporadic patients with PD and 1,167 control) were genotyped and the genetic association was analyzed.

Results

No significant association was found between allele A of rs9938550 and

SUBMITTER: Lu ZJ 

PROVIDER: S-EPMC5893344 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature